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On the target cell surface, IGF1 binds IGF1R which auto-phosphorylates and activates a signaling cascade mediated by the phosphorylation of the Insulin receptor substrate (IRS) proteins and other effectors leading to the activation of Mitogen-activated protein kinase (MAPK) and PI3K/AKT signaling pathways

Hunjan MK, Evered DF

[Araliaceae], activate the p62/Nrf2 pathway to suppress ROS and lipid peroxidation (Qiu et al., 2023)

GHRHR mRNA has been detected in the pituitary, gonads, placenta, kidney, hypothalamus, and many brain regions, although it is expressed predominantly in the anterior pituitary due to its dependence of Pit-1 (also known as GHF-1)

12 A concise representation of the application of nanotherapeutic agents for the treatment of depression is given in Figure 1