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In preclinical research, blocking NNMT raised NAD+ inside fat cells, increased their metabolic activity, and reduced fat-cell size notably without changes to diet
Clinical Principle Because the underlying pathophysiology of IC/BPS is unknown, treatment goals are to manage symptoms and optimize QoL
Its natural purpose is to protect the gut lining from the harsh acids of the stomach and to rapidly heal any ulcers or lesions

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Impaired forelimb function scoring (see 63, 64)
