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Cell Death & Disease, 11 (5), 312

Limitations and Research Status While preclinical data is extensive, large-scale human clinical trials are limited

Sodium oxide is added to the melt-quench-produced BGs primarily to lower the melting temperature and has the added benefit of increased solubility 6,16

Importantly, the group also prepared an additional analog bridged by methylene thioacetal, prepared from native IL-2 by reduction and subsequent CH 2 I 2 -mediated alkylation

The success of the treatment depends as much on the technique used as on the patient's rigor in following medical instructions after the procedure