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In residual triple-negative breast cancer (TNBC) cells following chemotherapy treatment (with either DNA-damaging agents or taxanes), both glucose and lactate flux into the TCA cycle were observed to be increased ( 3.2 Therapy-induced adaptations in mitochondrial redox state Reduction-oxidation (redox) chemical reactions involve the transfer of an electron between a reducing agent (electron donor) and an oxidizing agent (electron acceptor) ( 2

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