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Reconstitution: 3.0 mL bacteriostatic water per 10 mg blend vial gives 3.33 mg/mL total (1.67 mg/mL each) for accurate unit measurements

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Since IGFBPs normally sequester most circulating IGF-1, this escape from binding protein control creates much higher free (bioactive) concentrations at the injection site

The accurate framing is that NSI-189's "neurogenic" label rests on preclinical models plus a hippocampal-volume MRI marker not on a confirmed molecular target, and not on a demonstration that it increases neurogenesis in humans

14 , e12860 (2022)