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Author Contributions Concept and design: James R

[DOI] [PubMed] [Google Scholar] 11.Trixl L, Amort T, Wille A, Zinni M, Ebner S, Hechenberger C, Eichin F, Gabriel H, Schoberleitner I, Huang A, et al

The appearance of a pronucleus was used as the indicator of successful activation, suggesting that the oocyte had completed meiotic maturation and was capable of initiating embryonic development independently of fertilization

Since 2010, it has technically remained the only truly FDA-approved treatment specifically indicated for the treatment of chronic migraine prevention, up until Qulipta (Atogepant) became the first and only pill to receive FDA approval for chronic migraine in 2023