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The balanced ratio of GLP-1 to glucagon receptor activity ensures that the hyperglycemic potential of glucagon signaling is offset by the insulinotropic and appetite-suppressive effects of GLP-1 signaling, resulting in net improvements in both glycemic parameters and body weight

[27] [29] Particular caution should be used when prescribing phosphodiesterase type 5 (PDE5) inhibitors to patients receiving atazanavir

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