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After 2 hours, islets were subjected to either liraglutide (100 nM) (107, 108) or saline treatment for 12 hours (DART-Seq) (8, 85, 109) in order to assess changes in RNA expression or 24 hours (7, 85, 107) (IHC, active GLP-1 measurements) in order to assess changes in protein content, as previously validated (85)

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In clinical trials, 25 mg of the daily Wegovy pill produced an average 13.6% weight loss, which is close to the 14.9% seen with 2.4 mg weekly injections

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[1] What we discovered, however, is that these arent actually two separate problems