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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans

Weekly dosage schedule Starting dose: 0.25 mg weekly for first 4 weeks Titration phase: 0.5 mg weekly for 4 weeks and then, if tolerated, 1 mg weekly for 4 weeks Maintenance dose for long-term weight management: 1.7 mg once weekly for 4 weeks and then, if tolerated, 2.4 mg once weekly (maximum dose) Dosing considerations If you do not tolerate dose escalation, consult with your healthcare provider and consider delaying the dose escalation for at least 4 weeks

In an in vitro study, exendin-4 treatment in fat-loaded human hepatocytes appeared to protect the hepatocytes from fatty-acid-related death by inhibiting a dysfunctional endoplasmic reticulum stress response and reducing fatty acid accumulation [29]