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However, loss of lean muscle mass could be potentially detrimental to patients, especially those who are older or have chronic illnesses

Both are likely to require either significant real world observation in off-label use, or some form of RCT with careful observation

The most effective approach is targeted: support the specific bacteria and pathways that your gut needs during this transition, rather than throwing general solutions at the problem

It can be due to inadequate blood sugar control from the drug, being intolerable to the adverse effects such as nausea and vomiting, the cost of the medication, the preference for oral medication and not injections, the patient unable to reach their weight goal, weight gain and injections being painful to inject

Yes, particularly if there is a blockage or bloating