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People with higher body weight Body weight influences drug distribution and can affect the perceived strength of a starting dose

Muscle mass preservation is an important consideration given the risk of sarcopenic obesity: weight loss with GLP-1 RAs includes a lean mass component (approximately 25%-40% of total weight loss), though the clinical significance in MASLD patients without sarcopenia is uncertain

Turn first to metformin for pharmacologic treatment of type 2 diabetes

Mainly because I am not super consistent