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The TGA has specifically investigated the potential for reduced effectiveness of oral contraception when first taking or increasing the dose of tirzepatide ( Mounjaro ), concluding that this association could not be ruled out

Twelve-week studies were initially designed to obtain a quality assessment of the impact on HbA1C but have proven to be of insufficient duration to confidently assess weight loss relative to placebo, and especially differential efficacy to other weight lowering drugs

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According to the American Society of Anesthesiologists consensus guidelines, if the patient has reported gastrointestinal side effects of nausea or vomiting due to a GLP-1 receptor agonist, they must be considered at increased risk for complications requiring full-stomach precautions for anesthesia

Rapid dose escalation and higher maintenance doses are additional considerations