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To comprehensively evaluate the therapeutic effects of semaglutide on hepatic steatosis, future studies should incorporate complementary methods such as Oil Red O staining (Zhu et al., 2019), biochemical hepatic TG assays (Rong et al., 2024), or non-invasive imaging techniques such as magnetic resonance imaging with proton density fat fraction (MRI-PDFF) (Park et al., 2022)