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It also describes sustained 5 to 10% weight loss in longer-term use alongside lifestyle support

The SURMOUNT-1 trial (Jastreboff et al

GLP-1 agonists appear to prevent that significant drop while improving leptin sensitivity and thereby promote sustained weight loss

Since then, the evolution of GLP-1 receptor agonists has progressed from initial short-duration agents like exenatide, to intermediate-duration formulations such as liraglutide, and further to advanced long-acting options including dulaglutide and semaglutide (The two products received approval for marketing in the U.S

However, this event was associated with the concurrent use of ondansetron (an anti-nausea medication), not directly attributable to retatrutide itself