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Additionally, Lys17, upon further modification (e.g., K26 in Semaglutide), is expected to enhance the binding affinity of SR18 to serum albumin (Supplementary Figure S2), improving its in vivo pharmacological functions

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Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents

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Cumulative Effect: Semaglutide has a long half-life of about seven days

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