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For example, when rats are offered unlimited access to diets enriched in fat, carbohydrate, or protein, intra-VTA infusion of the GHSR antagonist GHRP over 14 days specifically lowers fat intake [77]

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The IGF-1 axis benefits from the same pause: it drifts back toward baseline instead of sitting chronically elevated, which is the safer position given GH/IGF-1s growth-promoting signaling

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