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GLP-1 therapy to treat obesity among members without diabetes: three-year persistence. 2024

2013, in press Action to Control Cardiovascular Risk in Diabetes (ACCORD)
Incretins are largely degraded by DPP-4 in vivo, which can be hindered by substitution of first three residues or increasing steric hindrance

Growing focus on personalized medicine and preventive care dries widespread acceptance of GLP-1 receptor agonists in various care settings

This is not the profound appetite suppression that comes later at higher doses
