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Hoechst 33342, Annexin V, and PI were also from Thermo Fisher Scientific (Waltham, MA)

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Nauck MA, Muus Ghorbani ML, Kreiner E, Saevereid HA, Buse JB, LEADER Publication Committee on behalf of the LEADER Trial Investigators Effects of liraglutide compared with placebo on events of acute gallbladder or biliary disease in patients with type 2 diabetes at high risk for cardiovascular events in the LEADER randomized trial

While early IR tyrosine phosphorylation and downstream AKT and MAPK activation were similar, RF-409 attenuated C-terminal serine phosphorylation of the receptor and altered adaptor phosphorylation, particularly within IRS2

Contact your clinical trial team for guidance, as missed-dose windows and instructions are defined by the trial protocol and may vary

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