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therefore, adopting strategies to minimize muscle and bone loss is prudent

10.1161/ATVBAHA.107.147835 [DOI] [PubMed] [Google Scholar] 121.Pacheco R, Martinez-Navio JM, Lejeune M, Climent N, Oliva H, Gatell JM, et al

February 2025: Novo Nordisk announced that semaglutide 2.4 mg would be available in Mexican pharmacies by April 2025, with an average 17.5% weight loss observed in pivotal trials

Some studies have reported that depression caused by chronic stress disrupts the BDNFtropomyosin related kinase B (TrkB) receptor signaling pathway in the PFC and hippocampus, and ultimately contributes to impaired synaptic maturation, synaptic protein synthesis, and glutamate receptor cycling ( Therefore, because neurotransmitter imbalance contributes to depressive behaviors in patients with depression as described above, the appropriate modulation of neurotransmitters in the brain is key to treating depression ( Figure 2 )