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Currently, orforglipron has not been approved for use in the UK, but approval for use in the US has been granted so its likely

Though the exact cause of this side effect is unclear, its thought that a buildup of acids in the small intestine is to blame for these symptoms
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Simon M.-C., Strassburger K., Nowotny B., Kolb H., Nowotny P., Burkart V., et al

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