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The model was adjusted for age, sex, HbA1c, LDL cholesterol, systolic blood pressure, BMI, smoking status, previous cardiovascular disease, and medication use (lipid-lowering, antidiabetic, and antihypertensive treatments)

Duration of benefits Obesity is a chronic disease, and withdrawal of AOMs in clinical trial extensions have found that participants regain up to two-thirds of their prior weight loss with associated reversion of cardiometabolic outcomes 73

The ultimate winner in this space will be a GLP-1 agonist that delivers sustained clinical benefits with an excellent long-term safety profile and minimal adverse effects

Brasted, M., White, C

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