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Rarer but more serious risks include acute pancreatitis and gallstone formation

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allow to dry Device Preparation : Check pen for damage Verify medication is clear and colorless (Zepbound) or clear and colorless to slightly yellow (Wegovy) Attach new needle to pen Prime pen according to manufacturer instructions (removes air) Injection : Pinch skin at injection site Insert needle at 90-degree angle Press injection button and hold until dose delivered (may take 5-10 seconds) Count slowly to ensure full dose delivery Remove needle and release skin Post-Injection : Do not rub injection site Apply gentle pressure if needed Dispose of used needle immediately in sharps container Recap pen and return to refrigerator For vial formulations with syringe (Zepbound vials): Preparation (same as above for site selection and cleaning) Dose Drawing : Remove vial protective cap Wipe rubber stopper with alcohol swab Draw air into syringe equal to prescribed dose Insert needle into vial and inject air Invert vial and slowly draw prescribed dose into syringe Check for air bubbles