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Thus, the action of JWU-A021 was evaluated in HEK-293 cells transfected with a wild-type (WT) TRPA1, an empty vector (EV), or a mutant (MT) C622S TRPA1 channel that has reduced sensitivity to electrophiles 14

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The clinical titration schedule uses 4-week intervals specifically to allow drug levels to stabilize before escalation

doi: 10.1186/s13293-016-0059-9 10 WangWVolkowNDBergerNADavisPBKaelberDCXuR
