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Incretins and the development of type 2 diabetes

They showed that semaglutide enhanced histological parameters of fibrosis and inflammation while decreasing hepatic expression of genes associated with fibrotic and inflammatory cascade: through proteomic profiling of serum from MASH patients treated with semaglutide, they detected 72 proteins linked to disease resolution and validated these findings in preclinical mouse models and an independent patient cohort [28]

Dietary modifications can substantially reduce nausea: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or spicy foods, which delay gastric emptying further Limit foods with strong odours that may trigger nausea Stay well-hydrated throughout the day with small, frequent sips of water Avoid lying down immediately after eating Consider bland, easily digestible foods such as toast, crackers, or rice during periods of nausea Timing and dose escalation are critical

instead, an individualised approach based on dietary assessment and blood tests is recommended, with particular attention to vitamin B12, vitamin D, calcium, and iron

However, most of these studies are retrospective, meaning they analyze existing data rather than testing treatments in real time