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If the price is high relative to the benefit, NICE can restrict access to specific patient groups (for example, only those with very high BMI or particular comorbidities), or reject NHS use altogether
Notably, SCFA-mediated GLP-1 release was abolished in Gpr43 -deficient mice, confirming receptor dependency (Psichas et al., 2015)
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There were no deaths in the finerenone group during the trial
