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By the end of week four, we know whether the patient tolerates the GLP-1 piece and we have a stable dose to layer onto

In a repeated self-administration paradigm that used freely moving mice with jugular catheters, exendin-4 (10 g/kg, i.p.) pretreatment shifted the cocaine dose-response curve downward by decreasing the total number of infusions earned for various unit doses of cocaine, suggesting a decrease in the reinforcing efficacy of cocaine [116]

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"The findings in our study reinforce that exercise cannot be optional for people taking these medications," Maharjan said in a statement