can you switch from semaglutide to retatrutide vs. semaglutide: A head-to-head comparison can i switch from semaglutide

GI side effects: nausea, vomiting, and diarrhea are common early on

The nausea window typically spans 4 to 24 hours post-injection, with intensity peaking around 8 to 16 hours

Over-the-counter remedies may be appropriate in some cases, but should only be used after discussion with a pharmacist or GP: Oral rehydration salts (such as Dioralyte) are recommended for diarrhoea-related fluid loss Loperamide may be considered for short-term management of loose stools, but must be avoided if you have a fever, blood or mucus in your stools, or if antibiotic-associated diarrhoea (including Clostridioides difficile ) is suspected seek pharmacist or GP advice first For constipation, macrogol-based laxatives (such as Movicol) are a reasonable first-line option in line with NICE CKS guidance on constipation in adults

doi: 10.1056/NEJMoa2413258

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