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Theoretical considerations suggest Retatrutides triple-agonist mechanism might produce more robust effects on reward circuitry, similar to its enhanced weight loss efficacy compared to single-agonist medications

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Intrauterine pregnancy If a non-ectopic pregnancy occurs with a Mirena IUD in place, there are still several risks, including sepsis, miscarriage and premature labor

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Rare adverse events, such as severe liver damage and kidney injury associated with oxalate nephropathy, have been reported but occur infrequently [25]

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