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Even small molecular differences can affect therapeutic performance and stability

This deliberate slowdown helps you feel fuller longer and eat less, but it also allows food to sit in your digestive tract longer than usual

Cholelithiasis was reported in 1 patient treated with exenatide

[17] Whilst semaglutide primarily targets appetite centres in the hypothalamus, the broader distribution of GLP-1 receptors means that central nervous system effects cannot be entirely excluded, though this remains speculative without specific clinical evidence

The results of these studies must be interpreted in the context of only a small number of the most severe and refractory of patients undergoing these invasive interventions