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GLP-1s may offer a dual benefit for patients with chronic conditions like diabetes or obesity who are also struggling with a substance use disorder: one medication can treat both conditions at once, Al-Aly says

As a neural repair protein, GLP-1 exerts anti-inflammatory and antioxidant effects, contributing to the protection of neurons and the promotion of neuronal cell proliferation and differentiation within the central nervous system [21,22]

There is no confirmed elevated risk of suicidality, but surveillance remains warranted

insulin glargine in high cardiovascular-risk type 2 diabetes), tirzepatide was associated with a reduction in albuminuria whereas insulin glargine showed an increase, supporting the hypothesis that greater weight loss and metabolic improvements can translate into larger albuminuria reductions [107]

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