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Macrolides can inhibit CYP3A4 by a mechanism called mechanism-based inhibition (MBI), which involves the formation of reactive metabolites that bind covalently and irreversibly to the enzyme, rendering it inactive

Akshay Sanan , MD, FACS, is a double board-certified facial plastic surgeon and founder of Dr

Moreover, exaggerated inflammatory disorders in Covid-19 due to the release of pro-inflammatory cytokines like IL-1, IL-6, and TNF- may lead to the development of systemic inflammation and cytokine storm (Zanza et al

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