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They stimulate insulin secretion, suppress glucagon release, and slow gastric emptying

Elashoff, M., Matveyenko, A

Tan and Murphy called that more than enough process, but Grossman claimed that without knowing the FDAs analytical parameters in advance, the compounders were shooting in the dark

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These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects