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Additionally, the GLP-1receptors have been identified in the GI tracts myenteric and submucosal neural plexuses (18, 19)

Maintain adequate hydration by sipping water throughout the day, use sugar-free xylitol gum to stimulate saliva production, optimize oral hygiene with fluoride toothpaste and alcohol-free mouth rinse, and consider using a bedroom humidifier at night

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Preclinical studies show that the central GIPR is essential to the additive effect to reduce food intake with combined GLP-1R and GIPR agonism [21, 27, 28, 67]