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Mechanistic investigations revealed OBBs dual regulatory capacity: (i) AMPK hyperphosphorylation-mediated bioenergetic enhancement through UCP1 upregulation, and (ii) inflammation resolution via inhibiting aberrant phosphorylation of IRS-1 coupled with coordinated modulation of immunometabolic signalingsuppressing proinflammatory mediators (MCP-1, CD68, Nos2, CD11c) while activating the downstream protein expression and phosphorylation (PI3K, p-Akt/Akt and p-GSK-3/GSK-3) [215]

Waist circumference, waist-to-hip ratio, and metabolic health markers can all support a case for treatment even when BMI alone does not quite meet the standard cutoff

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Other weight management agents such as Qsymia, orlistat, and phentermine are also available on our standard template commercial formularies