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Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low)

Heart palpitations during semaglutide treatment are a real concern for some patients

Discover how GLP-1 medications like Wegovy and Zepbound reduce triglycerides, LDL cholesterol, and cardiovascular risk through proven metabolic effects beyond weight loss alone.

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