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Contraindications and Cautions Most agents in this class carry a boxed warning for thyroid C-cell tumors observed in rodent studies

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Holst JJ, Andersen DB, Grunddal KV

Others hit a wall at 8%

Direct Myocardial Effects Although the presence of functional GLP-1 receptors on human ventricular cardiomyocytes remains a matter of debate, preclinical studies suggest potential direct cardioprotective effects