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The biggest error researchers make

Reduced gastrointestinal motility and altered drug absorption may require dose adjustments of medications including warfarin, direct oral anticoagulants, opioids, and antiepileptic agents

The magnitude of weight loss achieved with GLP-1 RAs often exceeds that seen with lifestyle interventions alone, potentially providing hope for adolescents who have struggled with traditional approaches

The review also emphasized that the renal and hepatic benefits of GLP-1 medicines appear mechanistically linked to both systemic metabolic improvements and local anti-inflammatory signaling

Limitations and Considerations Current Evidence Limitations The current evidence base for GLP-1 RAs in adolescents has several important limitations
