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These include pancreatitis (rare but reported in clinical trials and post-marketing surveillance), gallbladder disease, and acute kidney injury (particularly in the setting of severe dehydration from gastrointestinal effects)

2 Similarly, Krajewski et al 4 report reductions in HS lesion counts and inflammatory markers such as CRP but emphasize that these are closely linked to metabolic improvements, including weight loss and enhanced insulin sensitivity

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[14] In patients with diabetes, overly aggressive glycemic control or inadequate adjustment of concurrent diabetes medications (particularly insulin or sulfonylureas) may result in hypoglycemia or relative hypoglycemia, even if glucose values remain within normal range