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Additionally, the interaction between substance abuse and depression may worsen depressive symptoms and its prognosis, leading to a vicious cycle that further complicates metabolic health [48]
Front Synaptic Neurosci 14: 955258

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can improve mitochondrial health, reduce oxidative stress, and support metabolic balance (Cant et al

This may be because insurance coverage of the use of these agents is broader in T2DM than for obesity
