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Increased Insulin Secretion GLP-1 receptor agonists promote insulin secretion in a glucose-dependent manner, stimulating the pancreas to release insulin primarily when blood glucose levels are elevated

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doi: 10.3389/fphar.2025.1627691 Received 13 May 2025 Accepted 23 September 2025 Published 13 October 2025 Volume 16 - 2025 Edited by Ravinder Abrol, California State University, Northridge, United States Reviewed by Katherine N

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Foxo transcriptional factors can act as either transcriptional activators or repressors by forming different molecular complexes with various transcriptional modulators including b-catenin, STAT3 (Signal transducer and activator of transcription 3), Runx3 (Runt-related transcription factor 3), and Smad3 (Mothers against decapentaplegic homolog 3)