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The CuAAC reaction can be performed in a range of solvents, including mixtures of water and miscible organic solvents like alcohols, DMSO, DMF, and THF, while acetonitrile is typically avoided due to its strong coordinating ability toward Cu(I)

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Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimers disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial