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In an investigative report in partnership with KFF Health News, NBC News Anne Thompson reports on the growing cases of overdoses involving GLP-1 weight loss drugs.

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GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals.

High fill rates of GLP-1 receptor agonist prescriptions in those with mood disorders could indicate that multimorbidity begets more treatment.

As the interest in incretin-based therapies has risen substantially, we discuss how incretin-based therapies, including glucagon-like peptide-1 (GLP-1) receptor agonists and GLP-1 receptor agonists and glucose-dependent insulinotropic polypeptide (GIP) dual agonists, might improve reproductive function and could interact with the physiological metabolic changes ensuring a healthy pregnancy