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All of this stuff just scares the crap out of me, Randy Seeley concluded after enumerating the potential dangers to me

Any larger drops in the first few weeks are predominantly water, glycogen depletion, and reduced food volume in the digestive tract

it triggers glucose-dependent insulin release from the pancreas (meaning insulin goes up when blood sugar is high, not when it is already normal)

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Retatrutide takes roughly six weekly doses to reach a stable level, so the first couple of weeks after any increase are the least settled point to judge anything by