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This is particularly surprising given that i.c.v administration is a standard route to test central effects of drugs in animal studies, and a large number of studies have injected GLP1 or GLP1 receptor agonists and antagonists into the ventricular system in order to explore direct effects of GLP1 receptor activation within the CNS (Meeran et al., 1999

There are currently only a few FDA approved peptide medications

Review the sources used below for this article: JAMA Network

The researchers noted that semaglutide was also the most commonly prescribed GLP-1 medication during the study period, which may have provided greater statistical power to detect differences among medications

Researchers should follow all established laboratory handling, storage, and safety protocols when working with peptide materials