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These findings suggest a potential mechanism through which GLP-1 signaling may reduce glycation-related cellular stress

In these individuals, the anti-inflammatory effects may provide additional benefit beyond glycemic control

4 Clinical evidence In adults with obesity, 72 weeks of orforglipron treatment resulted in greater body-weight reductions than placebo, up to -11.2%, compared to -2.1% with placebo

Western Blot and Real-Time PCR The serum (5 L) was prepared and run through the NuPAGE gels and blotted with the indicated antibodies (see details in figure legends)

Kostev K, Ouwens M, Grandy S, Johnsson KM, Qiao Q