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Data from a phase 1 feasibility trial showed that treatment of adults with early-stage AD with a combination of dasatinib and quercetin was well tolerated, and promising results from an exploratory analysis indicated the potential reduction of inflammatory markers (Gonzales et al., 2023) consistent with responses observed in preclinical studies (Zhang et al., 2019b)
A decrease in the level of GLP-1R contributes to neurotoxicity mediated by microglia and astrocytes, exacerbating neuron death and convulsive activity [74]
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