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Neuroprotective Effect of GLP-1RAs Cognitive dysfunction is a neurodegenerative disorder that impairs multiple cognitive domains, including memory, language, executive function, and spatial orientation, with the extent of impairment correlating with disease severity.107 This spectrum ranges from mild cognitive impairment or mild neurocognitive disorder to more severe forms of dementia, including Alzheimers disease (AD), Parkinsons disease (PD), and vascular dementia