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GLP-1 receptor agonists also exert antioxidant, anti-inflammatory, and antifibrotic effects by downregulating pro-inflammatory pathways (e.g., nuclear factor-B), cytokines (e.g., transforming growth factor ), and T-cell proliferation [18]

So, GLP-1s lead to clinically significant weight loss rarely observed in intervention trials that use lifestyle interventions without medications

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Liraglutide and semaglutide, two types of GLP-1 RAs, resemble the native human GLP-1 hormone in their structure by 9497% and have a molecular weight of 3751.3 Da and 4113.6 Da, for liraglutide and semaglutide, respectively (PDB-101: Protein Data Bank, 2025a