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It is important to note that these metabolic adaptations are generally physiological responses to weight loss rather than pathological changes
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GLP-1RAs and SGLT2 inhibitors also have pleiotropic effects, including blood glucose-dependent and -independent mechanisms, effects on the reninangiotensinaldosterone system and favourable effects on left ventricular and renal functions [35, 36]
A cellular and molecular basis of leptin resistance
