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Interestingly, treatment of mouse cardiomyocytes with GLP-1 936 amide (a GLP-1 degradation product in vivo) resulted in Akt activation, extracellular regulated kinase (ERK) phosphorylation, and reduced apoptosis induced by hypoxia or hydrogen peroxide stress, implying an unconventional action of GLP-1 (Ban et al., 2010)

Obese subjects exhibit decreased heart rate variability likely due to an imbalance of sympathetic and parasympathetic activity (117)

Front Endocrinol (Lausanne) (2019) 10:155

The researchers found that the medication suppressed appetite, improved control of eating, and reduced food cravings, ad libitum energy intake, and body weight compared to the placebo